522 N. New Ballas, Suite 206
St. Louis, Missouri 63141
Phone : 314 473 1285
Fax : 314 473 1287
After Hours : 314 277 8782

..where everyone has a chance to start a family

Dr. Jacob

My interest in helping infertile couples started while I was a third year medical school student. I saw first hand the emotional distress infertile couple experienced while I was helping the attending infertility specialist in his office. The patient told me, “Since I am not able to have a baby, I feel I am an incomplete woman”. The tears rolling down her cheeks struck a chord in me and I decided then that I will dedicate my medical career helping infertile couples achieve their dream of having a baby. After I graduated from medical school and OB/GYN residency, I did a three year fellowship in Reproductive Endocrinology & Infertility at the Human Assisted Reproduction Ireland Unit of the Royal College of Surgeons, Rotunda Hospital, Dublin, Ireland. Here, I mastered all the advanced reproductive technologies and did research in the field of infertility. Our new Center for Reproductive Medicine & Robotic Surgery is a “dream come true” for me. The mission of my dream is simple: Make the dream of having a child affordable to all infertile couples by providing the best care, at an affordable price and in a friendly and compassionate environment. We are proud to offer a comprehensive array of services, in a responsive and efficient manner.  Our single office setting enables us to have complete control over your care which provides you with a convenience that other centers may not be able to offer. We also provide extended office hours to ensure your care fits into your busy schedule. My staff and I are committed to exceeding your expectations  and are confident you will find our office convenient, affordable, and run by a dedicated and caring staff.
Education

•  MD-University of Kerala, Medical School

• OB/GYN Residency-Washington Univ. School of Medicine, St. Louis             

•  Fellowship REI-Human Assisted Reproduction Ireland, Rotunda Hospital, Royal College of Surgeons in Ireland.

•  Diploma in Health Informatics-University of Dublin         

Specialized Training

Certified as a Robotic Surgeon for Minimally invasive Gynecologic surgery. (da Vinci Robotic systems.)

Honors and Awards

Honors in Biology, Chemistry and Physics

Honors in Internal Medicine, Obstetrics and Gynecology & Forensic Medicine, MD University of Kerala

Best Outgoing Postgraduate from Ob/Gyn Residency, University of Kerala, India

Organon Resident Research Award for Outstanding Research in Women’s Health-2002.

Wyeth Resident Reporter at ASRM Conference - 2004.

Teaching Title and Responsibilities

Clinical Assistant Professor of Obstetrics and Gynecology. Washington University School of Medicine, St. Louis.

Clinical Title and Responsibilities

Attending, OB/GYN & REI :-Barnes-Jewish Hospital,  Missouri Baptist Medical Center, Alton Memorial Hospital & St. Claire Health Center.

Medical Licensure

Missouri.

Illinois.

Board Certification

1996-M.R.C.O.G. Royal College of Obstetricians & Gynecologists, UK.

2000-Fellowship REI, RCSI, Dublin.

2006-American Board of Obstetrics and Gynecology, General Obstetrics and Gynecology, Board Certified, January 2006.

Major Invited Professorships and Lectureships

     1.  October 3, 1996    Obstetrical and Neonatal Management of Conjoined Twins.  Annual Meeting of the Irish and American Pediatric Society

            Dublin, Ireland.

    2.   September 21, 1999    Decision Support Systems in Medicine.  Mount Sinai Hospital.New York, New York.

    3.   September 22, 1999    Neural Networks, K Nearest Neighbor for Prediction Analysis.Harvard-MIT Medical Informatics Series.  Brigham and

           Women’s Hospital.  Boston, Massachusetts.

    4.   December, 1999.    IT in Medicine.  McGill University Grand Rounds. Montreal.

    5.   December 15, 1999    Expert Systems for Clinical Guidance in Narrow Domain Medical Fields. Blair Bell Research Society Competition.  Royal

          College of Obstetricians & Gynecologists.  UK.

    6.  January 4, 2000    Prediction of Ideal Number of Embryos to be Transferred in Assisted Reproduction Treatment Programs – Project Report.

          Harvard Medical School.

    7.  January 31, 2000    Medical Decision Support Systems – Prediction of ART Outcome Using Artificial Neural Networks.  Cleveland Clinic

         Foundation. Cleveland, Ohio.

    8. May 8, 2004    Current Theories and Management of PCOS.  Washington University School of Medicine.  St. Louis, Missouri.

    9.  March 16, 2005    Current Theory and Management of Polycystic Ovary Syndrome.  Alton Memorial Hospital.  Alton, Illinois.

   10.  June 14, 2005    Deleterious Effect of Hyperinsulinemia on Embryo Glucose Metabolism: Treatment Options for PCOS.  Rotunda Hospital.

            University of Dublin. Dublin, Ireland.

   11.  July 2005    Hyperinsulinemia and PCOS:  Affect on Reproductive Potential.  SAT Hospital, Medical College TVM.  University of Kerala.  Kerala,

           India.

    12.  July 2006    Assisted Reproductive Treatments – Basics for the primary care physician, Alton Memorial Hospital, Alton, Illinois.

    13.  August 2007    Grand rounds- Anderson Hospital – Infertility for primary care physician.

Research Support

Non-Governmental Eclampsia Research Grant, University of Kerala, India - $5,000

Bibliography

Peer Reviewed Manuscripts:

1.Jacob S, Moley KH.  Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies.  Pediatric Research  2005; 58:437-446.

 2.Harrison RF, Jacob S, Spillane H, Mallon E, Hennelly B.  A prospective randomized clinical trial of differing starter doses of recombinant follicle stimulating hormone (follitropin-b) for first time IVF/ICSI cycles.  Fertility and Sterility  2001; 75:23-31.

3.Cunningham P, Carney J, Jacob S.  Stability problems with artificial neural networks and the ensemble solution.  Artificial Intelligence in Medicine  2000; 20:217-225.

4.Hennely B, Harrison RF, Jacob S, Kelly J, Barrett T.  Spontaneous conception after Successful attempt at IVF/ICSI.  Fertility and Sterility  2000; 73:774-778.

5. Jacob S, Spillane H, Keane D, Waite K, McSorley G, Harrison RF.  Initial experiences of a testicular sperm extraction programme for assisted reproduction in Ireland. Irish Journal of Medical Science  2000; 169(1):26-29.

6. Jacob S, Byrne P, Harrison RF.  Symptomatic cystic swelling at the root of the neck with Left sided pleural effusion as presentation of severe ovarian hyperstimulation syndrome. British Journal of Obstetrics and Gynecology  1999; 106:986-988.

7. Jacob S.  Price and lack of data precludes use of recombinant FSH.  Trends in Urology, Gynecology and Sexual Health  1999 Supplement.

8. Jacob S, Drudy L, Conroy R, Harrison RF.  Outcome from consecutive IVF/ICSI Attempts in the final group treated with urinary gonadotrophins and the first group Treated with recombinant FSH.  Human Reproduction  1998; 13:1783-1787.

9. Jacob S, Lalitha K, Gopalakrishnan K, Nair K, Sankarnarayan R.  Malignant ovarian Tumors – a profile.  Journal of Obstetrics and Gynecology of India  1993; 43:413-417.

Abstracts

1.    Jacob S, Gopalakrishnan K, Lalitha K. Standardized clinical trial of magnesium sulphate regime in comparison with MKK menon’s lytic cocktail regime in the management of eclampsia.  The 27th British Congress of Obstetrics and Gynecology.  London, 1995  Abstract #303.  Results referenced in the systematic review clinical evidence issue 6 December 2001, BMJ Publishing Group, London.

2.    Jacob S, O’Donoghue M, Jenkins DM, Collins JK, Cole MM, O’Shea R.  Comparative Study of sperm deoxyribo nucleic acid (DNA) content and damage between fertile and Infertile men using flow cytometry and gel electrophoresis.  Fertility and Sterility 1997; 69:S31.

3.    Jacob S.  Flow cytometry and gel electrophoresis – a novel technique to assess sperm DNAcontent and damage in fertile and infertile men.  EAGO Book of Abstracts, p. 5. May 10-14, 1998.

4.    Jacob S, Durdy L, Conroy R, Harrison RF.  Comparitive study of clinicaloutcome of consecutive IVF/ICSI cysles treated with hMG and FSHr.  Fertility and Sterility 1998; 70(3):S92-93.

5.    Jacob S, Cunningham P, Harrison RF.  Prediction of assisted reproduction treatment outcome using artificial neural networks.  Fertility and Sterility  1999; 72:S167.

6.    Jacob S, Conroy R, Harrison RF.  Predictive value of day 3 FSH in young women (<35yrs) undergoing assisted production treatment (ART).  Fertility and Sterility 2000; 74:S171.

7.    Chang AS, Jacob S, Moley K.  Effects of hyperglycemia on oocyte maturation and Development.  2004; SGI Abstract #951050.